KPV (Research-Grade Peptide)

α-MSH–derived tripeptide (Lysine–Proline–Valine) — for laboratory research only

Product Overview

KPV (Lysine–Proline–Valine) is a synthetic tripeptide corresponding to a short sequence derived from
α-melanocyte-stimulating hormone (α-MSH). In the scientific literature, KPV has been used as a research reagent
in experimental systems evaluating inflammatory and immune signaling readouts. Supplied as high-purity lyophilized
powder, this material is intended strictly for research use and not for human or veterinary administration.

Research Highlights

• PepT1-Mediated Uptake (Preclinical): A study in Gastroenterology reported that KPV is transported via PepT1
  and was associated with reduced inflammatory readouts in intestinal/immune cell systems and experimental colitis models.
  Gastroenterology (2007)
• Murine Colitis Models (Preclinical): An Inflammatory Bowel Diseases article reported anti-inflammatory effects of KPV
  in two murine colitis models, noting partial independence from MC1R signaling in their experimental setting.
  Inflammatory Bowel Diseases (2008)
• Colon-Targeted Nanoparticle Delivery (Preclinical): A Gastroenterology paper described nanoparticle-based delivery of KPV
  targeted to the colon and evaluated outcomes in a mouse model of colitis.
  Gastroenterology (2009)
• Hyaluronic Acid–Functionalized Nanoparticles (Preclinical): In Molecular Therapy, investigators reported HA-functionalized,
  KPV-loaded nanoparticles studied in vitro and in vivo in ulcerative colitis research models, including mucosal-healing and inflammation endpoints.
  Molecular Therapy (2017)

Product Details & Handling

• Synonyms: KPV; Lys-Pro-Val; Lysine–Proline–Valine
• Form: Lyophilized powder, supplied in sterile vials
• Purity: ≥ 98% (Certificate of Analysis provided)
• Storage: Store at –20 °C; protect from light and moisture
• Handling: Use only in controlled laboratory settings with appropriate PPE; consult SDS for detailed safety information

Legal Disclaimer

This product is provided strictly for laboratory research use only.
It is not intended for human or veterinary consumption, therapeutic, diagnostic, or clinical application.
Customers are responsible for compliance with all applicable laws and institutional policies.
KPV is not approved by the FDA as a drug, supplement, or treatment.
Windy City Peptide does not provide medical advice or support related to human use.